Outcome Prediction in Patients With Large B-cell Lymphoma Undergoing Chimeric Antigen Receptor T-cell Therapy

Outcome Prediction in Patients With Large B-cell Lymphoma Undergoing Chimeric Antigen Receptor T-cell Therapy

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The introduction of chimeric antigen receptor (CAR) T-cell therapy has led to a fundamental shift in the management of relapsed and refractory large B-cell lymphoma.However, our understanding of risk factors associated with non-response is still insufficient and the search for predictive biomarkers continues.Some parameters measurable on 18F-fluorodeoxyglucose positron emission tomography (PET) may 3 piece horse wall art be of additional value in this context.A total of 47 individuals from three German university centers who underwent re-staging with PET prior to CAR T-cell therapy were enrolled into the present study.

After multivariable analysis considering tumor characteristics and patient factors that might affect progression-free survival (PFS), we investigated whether metabolic tumor volume (MTV) or maximum standardized uptake value (SUVmax) further improve risk stratification.Their most suitable cut-offs were determined by Cox and logistic regression.Forward selection identified 2000 bmw 528i front bumper extra-nodal disease as the most predictive factor of those routinely available, and we found it to be associated with significantly inferior overall survival after CAR T-cell treatment (P = 0.012).

Furthermore, patients with MTV and SUVmax higher than the optimal threshold of 11 mL and 16.7, respectively, experienced shorter PFS (P = 0.016 and 0.002, respectively).

Hence, these risk factors might be useful for selection of individuals likely to benefit from CAR T-cell therapy and their management.